2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N8453
    Macranthoin G 159934-13-1 98%
    Macranthoin G is an inhibitor of p38 MAPK. Macranthoin G protects the cytotoxicity induced by Aβ or hydrogen peroxide in neuronal cells by downregulating p38 MAPK. Macranthoin G can used in study Alzheimer’s Disease.
    Macranthoin G
  • HY-N8671
    Withanoside V 256520-90-8 98%
    Withanoside V, a withanolide glycoside, exhibits inhibitory activity for tachyphylaxis to Clonidine in isolated guinea-pig ileum.
    Withanoside V
  • HY-N8730
    7,8,3′,4′-Tetramethoxyflavone 65548-55-2 98%
    7,8,3 ',4 '-Tetramethoxyflavone is an extract isolated from natural pomegranate juice and seeds. 7,8,3 ',4' -Tetramethoxyflavone has a protective effect on the neurotoxicity of paraquat-induced Parkinson's disease mouse model .
    7,8,3′,4′-Tetramethoxyflavone
  • HY-N8755
    Chikusetsusaponin Ib 59252-87-8 98%
    Chikusetsusaponin Ib has anti-Alzheimer's disease activity and is a potent AChE inhibitor.
    Chikusetsusaponin Ib
  • HY-N8764
    Decaffeoylacteoside 61548-34-3 98%
    Decaffeoylacteoside is an inhibitor of AChE/BChE/LOX with moderate activity.
    Decaffeoylacteoside
  • HY-N8765
    Methyl 2-(5-acetyl-2,3-dihydrobenzofuran-2-yl)propenoate 617722-55-1 98%
    Methyl 2-(5-acetyl-2,3-dihydrobenzofuran-2-yl)propenoate can be isolated from roots of Microglossa Pyrifolia. Microglossa Pyrifolia roots has analgesic and hepatic activities.
    Methyl 2-(5-acetyl-2,3-dihydrobenzofuran-2-yl)propenoate
  • HY-N8800
    3α-Hydroxytirucalla-7,24-dien-21-oic acid 82509-40-8 98%
    3α-Hydroxytirucalla-7,24-dien-21-oic acid is a tirucallane triterpene isolated from the oleoresin of Protium hebetatum Daly.
    3α-Hydroxytirucalla-7,24-dien-21-oic acid
  • HY-N8835
    Cannabisin D 144506-19-4 98%
    Cannabisin D inhibits proliferation and migration of glioblastoma cells through MAPKs signaling.
    Cannabisin D
  • HY-N8903
    Mumefural 222973-44-6 98%
    Mumefural is a bioactive component of the processed fruit of Prunus mume Sieb. Mumefural inhibits platelet aggregation. Mumefural shows anti-thrombotic effects and ameliorates cognitive impairment.
    Mumefural
  • HY-N8931
    Monomethyl lithospermate 933054-33-2 98%
    Monomethyl lithospermate activates the PI3K/AKT pathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of rats with middle artery occlusion (MCAO) and improved nerve damage in rats with ischemic stroke (IS).
    Monomethyl lithospermate
  • HY-N9085
    Neuchromenin 180964-26-5 98%
    Neuchromenin is a microbial melabolite that can be isolated from the culture broth of Eupenicillium javanicum var. meloforme PFll81. Neuchromenin induces neurite outgrowth of PC12 cells.
    Neuchromenin
  • HY-N9095
    Curculigoside C 851713-74-1 98%
    Curculigoside C is a phenolic glucoside with potent antioxidative and neuroprotective activities. Curculigoside C shows IC50 values of 0.25 mM and 0.88 mM for hydroxyl radicals and superoxide anion radicals, respectively.
    Curculigoside C
  • HY-N9096
    Gentiside B 1225022-67-2 98%
    Gentiside B has neuritogenic activity and induce neurite outgrowth. Gentiside B can be isolated from the root and rhizome of Gentiana rigescens. Gentiana has hepatoprotective, anti-inflammatory, analgesic, antiproliferative and antimicrobial effects.
    Gentiside B
  • HY-N9141
    Nantenine 2565-01-7 98%
    Nantenine is a serotonergic receptor antagonist. Nantenine selectively inhibits the contractile response of tissues to serotonin. Nantenine can be isolated from Nandina domestica.
    Nantenine
  • HY-N9147
    1-Hydroxy-N-methylacridone 16584-54-6 98%
    1-Hydroxy-N-methylacridone is an acridone alkaloid from Boronia lanceolate.
    1-Hydroxy-N-methylacridone
  • HY-N9283
    1,2-Diacetoxy-4,7,8-trihydroxy-3-(4-hydroxyphenyl)dibenzofuran 146905-24-0 98%
    1,2-Diacetoxy-4,7,8-trihydroxy-3-(4-hydroxyphenyl)dibenzofuran, isolated from the edible mushroom Sarcodon leucopus, has antioxidant effects in the DPPH scavenging assay with the IC50 of 28 μM, inhibits malondialdehyde (MDA) with the IC50 of 71 μM, and inhibits α-glucosidase with the IC50 of 6.22 μM.
    1,2-Diacetoxy-4,7,8-trihydroxy-3-(4-hydroxyphenyl)dibenzofuran
  • HY-N9335
    Myrciacetin 203734-35-4 98%
    Myrciacetin is a flavonoid from Rhododendron dauricum. Myrciacetin is against rat lens aldose reductase with an IC50 of 13 μM.
    Myrciacetin
  • HY-N9338
    Guattegaumerine 21446-35-5 98%
    Guattegaumerine is a bisbenzylisoquinoline alkaloid?with antimitotic, cytotoxic and neuroprotective activities.
    Guattegaumerine
  • HY-N9373
    Bacoside A2 58798-95-1 98%
    Bacoside A2 is a triterpenoid saponin.
    Bacoside A2
  • HY-N9414
    Acetoxyvalerenic acid 84638-55-1 98%
    Acetoxyvalerenic acid is a natural compound that could be found in valerian.
    Acetoxyvalerenic acid
Cat. No. Product Name / Synonyms Application Reactivity